Enhancers not required

Enhancers not required

Laboratory mice with over half a megabase of DNA upstream of their Myc gene removed still thrive in the absence of stress.

Ultraconserved Enhancers Are Required for Normal Development.

Non-coding "ultraconserved" regions containing hundreds of consecutive bases of perfect sequence conservation across mammalian genomes can function as distant-acting enhancers. However, initial deletion studies in mice revealed that loss of such extraordinarily constrained sequences had no immediate impact on viability. Here, we show that ultraconserved enhancers are required for normal develop...

is evaluation of hepatitis a immunity required or not?

Publication Ethics: Many Facets, Collaboration Required

Sir, the recent publication on “Publication Ethics” is very interesting (1). The article by Fazly Bazzaz and Sadeghi demonstrated many interesting cases                   of misconducts. Indeed, the misconducts can be seen  in many ways. As mentioned in the present publication, both author and editor can perform publication misconducts. Nevertheless, the problem has many more facets. Sometimes,...

Genetic enhancers.

A genetic enhancer is a mutation in one gene that intensifies the phenotype caused by a mutation in another gene. The phenotype of the double mutant is much stronger than the summation of the single mutant phenotypes. The isolation of enhancers can lead to the identification of interacting genes, including genes that act redundantly with respect to each other. Examples in Caenorhabditis elegans...